Acetone → HCID 178488037, compound

Participants

Reaction Steps

Acetone (75 mL) was added to a solution of esomeprazole (10.1 g, 29.2 mmol; 1.1% sulfone, 2.5% R-enantiomer) in methyl isobutyl ketone (75 mL). 30% sodium methoxide in methanol (5.7 mL, 30.7 mmol) was added in 15 min. The resulting slurry was stirred overnight at room temperature. The solid was collected by filtration, rinsed with acetone (2×12 mL) and dried under reduced pressure at 50° C. to yield esomeprazole sodium. Yield: 6.5 g (61%) Sulfone content: 0.06%. R-enantiomer content: 0.00%.

Provenance & Evidence