Methanol → HCID 178488037, compound

Participants

Reaction Conditions

Reaction Steps

A solution of esomeprazole (19.5 g, 56.5 mmol; 1.3% sulfone, 1.05% R-enantiomer) in methyl ethyl ketone (120 mL) was cooled to 15° C. 30% sodium methoxide in methanol (10.7 mL, 57.6 mmol) was added in 15 min. Subsequently, the solution was stirred at 27° C. A solid started to crystallize. The resulting slurry was stirred overnight at room temperature. The solid was collected by filtration, rinsed with methyl ethyl ketone (2×20 mL) and dried under reduced pressure at 50° C. to yield esomeprazole sodium. Yield: 12.4 g (60%). Sulfone content: 0.06%. R-enantiomer content: 0.00%.

Provenance & Evidence