Potassium bisulfate → Flupyradifurone

Participants

Reaction Steps

0.6 g of potassium hydrogensulphate was added at room temperature to a suspension of 1.0 g of isopropyl 2-isopropoxy-4,5-dihydro-4-oxofuran-3-carboxylate and 0.85 g of N-[(6-chloropyridin-3-yl)methyl]-2,2-difluoroethylamine in 15.8 g of butyronitrile. The mixture was heated to reflux for 5 hours. Subsequently, it was cooled to room temperature and washed with 10 ml of water. The solvent was removed under reduced pressure. This gave 1 g of 4-[[(6-chloropyridin-3-yl)methyl](2,2-difluoroethyl)amino]furan-2(5H)-one (this corresponds to 95% yield).

Provenance & Evidence