反应详情

Ethyl 2-(1-methyl-4-(4-pentylphenylsulfonamido)piperidin-4-yl)acetate (100 mg, 0.244 mmol) was treated with MeI as described in Example 2a to yield crude title compound (133 mg, 98%) which was used without further purification. 1H NMR (400 MHz, CDCl3) δ 7.77 (d, 2H, J=8.0 Hz), 7.33 (d, 2H, J=8.0 Hz), 6.05 (s, 1H), 3.98 (q, 2H, J=6.7), 3.79-3.70 (m, 2H), 3.65-3.60 (m, 5H), 3.40 (s, 3H), 2.69 (t, 2H, J=7.0 Hz), 2.54 (s, 2H), 2.49-2.43 (m, 4H), 1.67-1.61 (m, 2H), 1.38-1.32 (m, 4H), 1.17 (t, 3H, J=6.4 Hz), 0.91 (t, 3H, J=6.7 Hz); MS ESI 425.3 [M+H]+, calcd for [C22H36N2O4S+H]+ 425.60.