Methyl iodide → 4-(2-Ethoxy-2-oxoethyl)-1,1-dimethyl-4-(5-phenethylfuran-2-carboxamido)-piperidinium iodide

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Reaction Steps

Ethyl 2-(1-methyl-4-(5-phenethylfuran-2-carboxamido)piperidin-4-yl)acetate (25 mg, 0.063 mmol) was treated with MeI (38 uL, 0.630 mmol) as described in Example 2a to yield crude title compound (32 mg, 94%) which was used without further purification. NMR (400 MHz, CD3OD) δ 7.29-7.16 (m, 5H), 7.07 (s, 1H), 6.20 (s, 1H), 4.10 (q, 2H, J=7.2 Hz), 3.56-3.46 (m, 4H), 3.23 (s, 3H), 3.21 (s, 3H), 3.03 (s, 4H), 3.01 (s, 2H), 2.91-2.83 (m, 2H), 2.29-2.19 (m, 2H), 1.17 (t, 3H, J=7.2 Hz); MS ESI 414.1 [M+H]+, calcd for [C24H32N2O4+H]+ 413.53.

Provenance & Evidence