Methyl iodide → 3-(2-Ethoxy-2-oxoethyl)-1,1-dimethyl-3-(3-(4-octylphenyl)ureido)pyrrolidinium iodide
Reaction equation
[CH3:1][N:2]1[CH2:6][CH2:5][C:4]([CH2:25][C:26]([O:28][CH2:29][CH3:30])=[O:27])([NH:7][C:8]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])=[CH:13][CH:12]=2)=[O:9])[CH2:3]1.[CH3:31][I:32]>>[I-:32].[CH2:29]([O:28][C:26](=[O:27])[CH2:25][C:4]1([NH:7][C:8]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])=[CH:13][CH:12]=2)=[O:9])[CH2:5][CH2:6][N+:2]([CH3:31])([CH3:1])[CH2:3]1)[CH3:30]Participants
3
Procedure
According to the method described in example 2a, ethyl 2-(1-methyl-3-(3-(4-octylphenyl)ureido)pyrrolidin-3-yl)acetate was reacted with methyl iodide to give the title compound as a white solid (31 mg, quantitive). MS ESI 432.4 [M]+, calcd for [C25H42N3O3+] 432.32
Sources & evidence
- ORD record
- ord-e5a2a71b8ed24e7293bce38e8a275d70
- Source dataset
- uspto-grants-2014_03
- Patent number
- US08680282B2
Reaction notes
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