Potassium Carbonate → HCID 59627242, compound

Participants

Reaction Steps

To a solution of 3-chloro-1-phenylpropan-1-one (36 g, 214 mmol) in acetonitrile (400 mL) were added (S)-1-(4-bromophenyl)ethanamine (51 g, 256 mmol), K2CO3 (59 g, 428 mmol) and KI (71 g, 428 mmoL), and the mixture was refluxed overnight. The reaction mixture was filtered, and the filtrate was concentrated to give the crude (S)-3-(1-(4-bromophenyl)ethylamino)-1-phenylpropan-1-one (68 g), which was used to the next step without purification.

Provenance & Evidence