HCID 58237947, compound → HCID 44194570, compound

Participants

Reaction Steps

To a solution of ethyl 3-(2-((S)-1-(4-bromophenyl)ethylamino)ethyl)-3-phenylhex-5-enoate (4.6 g, 9.1 mmol) in anhydrous toluene (80 mL) was heated to reflux for 2 days. The reaction was concentrated to give the crude (S)-4-allyl-1-((S)-1-(4-bromophenyl)ethyl)-4-phenylpiperidin-2-one. The residue was purified by column chromatography to give the final product (1.2 g, 33%). 1H NMR (CDCl3): δ 1.13 (m, 3H), 1.76 (m, 1H), 1.97 (m, 1H), 2.24 (m, 1H), 2.43 (m, 2H), 2.57 (m, 2H), 2.94 (m, 1H), 4.89 (m, 2H), 5.35 (m, 1H), 6.01 (m, 1H), 7.03 (m, 2H), 7.21 (m, 3H), 7.30 (m, 2H), 7.42 (m, 2H).

Provenance & Evidence