反应详情

3-Methoxy-isoxazole-5-carboxylic acid methyl ester (prepared according to Eur. J. Org. Chem., 1998, 473) (1.0 g, 6.4 mmol) was dissolved in methanol (30 ml) and sodium borohydride (300 mg, 8.0 mmol) was added in portions. The mixture was stirred for 1 hour at room temperature, concentrated and the residue dissolved in dichloromethane (30 ml). The solution was washed with water, dried over magnesium sulfate and concentrated to give the product as a concentrated solution in dichloromethane. The solution was used without further purification.

1. concentrationconcentrated
2. dissolutionthe residue dissolved in dichloromethane (30 ml)
3. washThe solution was washed with water
4. dry with materialdried over magnesium sulfate
5. concentrationconcentrated
6. customto give the product as a concentrated solution in dichloromethane
7. customThe solution was used without further purification