4-Bromobenzaldehyde → HCID 59327809, compound

Participants

Reaction Conditions

Reaction Steps

4-butyl-N-(2,4-difluorophenyl)benzeneamine (30 m mol)), 4-bromobenzaldehyde (34 m mol)), tris(dibenzylideneaceton)dipalladium(O) (0.5 m mol)), tris-tert-butylphosphine (0.9 m mol)), and sodium-tert-butoxide (40 m mol)) were dissolved in toluene (100 ml) in a 250 ml tri-neck-round bottom flask and then stirred in a bath of 100° C. for 24 hours. After the reaction was terminated, the toluene was removed from the solution. After extraction was performed on the solution using dichloromethane and water, reduced pressure and distillation were performed on the resulting solution. After a silica gel column chromatography, the solvent was reduced in pressure and distilled, thereby obtaining 4-(N-(4-butylphenyl)-N-(2,4-difluorophenyl)amino)benzaldehyde liquid having 7.1 g.

Provenance & Evidence