Acetone → HCID 58070862, compound

Participants

Reaction Conditions

Reaction Steps

Polyphosphoric acid (5 g) is added to a warm (55° C.) solution of ([4-benzyloxy-2,6-dimethylphenyl]furan-2-yl)methanol (32 g) in a mixture of acetone (400 ml) and water (100 ml) and the mixture is heated at 55° C. for 20 hours. The reaction mixture is cooled to room temperature and most of the acetone is removed under reduced pressure. The mixture is extracted with diethyl ether (3×250 ml), and the organic fractions are washed with saturated aqueous sodium bicarbonate solution (2×200 ml), dried over anhydrous magnesium sulfate, filtered and the filtrate is evaporated under reduced pressure. The crude product (30.9 g) is used for the next step without further purification.

Provenance & Evidence