Triethylamine → HCID 58070838, compound

Participants

Reaction Steps

A mixture of 2-(4-benzyloxy-2,6-dimethylphenyl)hexahydro-4,7-ethanoindene-1,3-dione (2.9 g, 0.008 mol), pivaloyl chloride (1.5 ml, 0.012 mol), triethylamine (2 ml, 0.0014 mol) and dichloromethane (100 ml) is stirred at room temperature for 3 hours. The reaction mixture is next evaporated and the crude product is dissolved in dichloromethane, absorbed on to silica then purified by flash column chromatography (20% ethyl acetate in hexanes as eluant) to afford 2,2-dimethylpropionic acid 2-(4-benzyloxy-2,6-dimethylphenyl)-3-oxo-3a,4,5,6,7,7a-hexahydro-3H-4,7-ethanoinden-1-yl ester.

Provenance & Evidence