HCID 58070838, compound → HCID 58070830, compound

Participants

Reaction Steps

To a solution of 2,2-dimethylpropionic acid 2-(4-benzyloxy-2,6-dimethylphenyl)-3-oxo-3a,4,5,6,7,7a-hexahydro-3H-4,7-ethanoinden-1-yl ester (2.8 g, 0.006 mol) in methanol (250 ml) is added 10% palladium on carbon (0.50 g), and the suspension is stirred under a 4 bar hydrogen pressure for 5 hours. The reaction mixture is then filtered through a pad of diatomaceous earth and the filtrate is evaporated under reduced pressure. The crude product is triturated with diethyl ether to afford 2,2-dimethylpropionic acid 2-(4-hydroxy-2,6-dimethylphenyl)-3-oxo-3a,4,5,6,7,7a-hexahydro-3H-4,7-ethanoinden-1-yl ester.

Provenance & Evidence