Hydrochloric Acid → HCID 66709744, compound

Participants

Reaction Steps

To a solution of 2,2-dimethylpropionic acid 2-(4-hydroxy-2,6-dimethylphenyl)-3-oxo-3a,4,5,6,7,7a-hexahydro-3H-4,7-ethanoinden-1-yl ester (1.3 g, 0.0034 mol) in methanol (50 ml) is added potassium carbonate (2.35 g, 0.017 mol), and the suspension is stirred at room temperature for 2 hours. The reaction mixture is carefully acidified with 2M hydrochloric acid and extracted with ethyl acetate. The organics are separated, dried over anhydrous magnesium sulfate, filtered and the filtrate is evaporated to afford 2-(4-hydroxy-2,6-dimethylphenyl)hexahydro-4,7-ethanoindene-1,3-dione as a white solid.

Provenance & Evidence