反应详情

To a solution of 2-(4-benzyloxy-2,6-dimethylphenyl)-3-methoxycyclopent-2-enone (1.50 g, 3.59 mmol) in ethanol (10 ml) is added 5% palladium on carbon (0.150 g), and the suspension is stirred for 4 hours under a 4 bar hydrogen atmosphere. The reaction mixture is then filtered through diatomaceous earth, and the filtrate is concentrated in vacuo then purified by flash column chromatography to afford 2-(4-hydroxy-2,6-dimethylphenyl)-3-methoxy-5-(tetrahydropyran-4-ylmethyl)cyclopent-2-enone.

1. filtrationThe reaction mixture is then filtered through diatomaceous earth
2. concentrationthe filtrate is concentrated in vacuo
3. customthen purified by flash column chromatography