反应详情

The title compound was prepared in a manner analogous to Intermediate 2, substituting (1R,6S)3,8-diaza-bicyclo[4.2.0]octane-3-carboxylic acid tert-butyl ester for 3,8-diaza-bicyclo[4.2.0]octane-3-carboxylic acid tert-butyl ester and 2-chloro-4,6-dimethyl-pyrimidine for 2-chloro-quinoxaline in Step A. MS (ESI) mass calcd. for C12H18N4, 218.3; m/z found, 219.2 [M+H]+. 1H NMR (CDCl3): 6.32 (s, 1H), 4.25-4.16 (m, 1H), 4.03 (t, J=7.6, 1H), 3.75 (dd, J=7.9, 3.1, 1H), 3.62 (dd, J=14.5, 1.6, 1H), 3.15-3.05 (m, 1H), 2.94 (dd, J=14.5, 3.8, 1H), 2.67-2.56 (m, 2H), 2.28 (s, 6H), 2.11-1.98 (m, 2H), 1.77-1.64 (m, 1H).