HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloro-2,5-dimethylpyrazine → (1R,6S)-8-(3,6-Dimethyl-pyrazin-2-yl)-3,8-diaza-bicyclo[4.2.0]octane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloro-2,5-dimethylpyrazine | HCID 66771 | — |
| Reactant | 2-Chloroquinoxaline | HCID 238938 | — |
| Reactant | Tert-butyl 3,8-diazabicyclo[4.2.0]octane-3-carboxylate | HCID 43810891 | — |
| Reactant | 2-(3,8-Diaza-bicyclo[4.2.0]oct-8-yl)-quinoxaline | HCID 67116651 | — |
| Product | (1R,6S)-8-(3,6-Dimethyl-pyrazin-2-yl)-3,8-diaza-bicyclo[4.2.0]octane | HCID 68157557 | — |
Reaction Steps
The title compound was prepared in a manner analogous to Intermediate 2, substituting (1R,6S)-(3,8-diaza-bicyclo[4.2.0]octane-3-carboxylic acid tert-butyl ester for 3,8-diaza-bicyclo[4.2.0]octane-3-carboxylic acid tert-butyl ester and 3-chloro-2,5-dimethyl-pyrazine for 2-chloro-quinoxaline in Step A. MS (ESI) mass calcd. for C12H18N4, 218.30. The compound was used as such in the subsequent reactions.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08680275B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-6f88fd13f75648bfbc14abc6abe29524 |
| Source note | uspto-grants-2014_03 |