5-Fluoro-2-iodobenzoic acid → 2-Fluoro-6-(2H-1,2,3-triazol-2-yl)benzoic acid

HRID 1193067Notes

Reaction equation

HRID 1193067 reaction equation
F[C:2]1[CH:3]=[CH:4][C:5]([N:11]2[N:15]=[CH:14][CH:13]=[N:12]2)=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].[F:16]C1C=CC(I)=C(C=1)C(O)=O>>[F:16][C:10]1[CH:2]=[CH:3][CH:4]=[C:5]([N:11]2[N:15]=[CH:14][CH:13]=[N:12]2)[C:6]=1[C:7]([OH:9])=[O:8]

Participants

3

Reactant 2

HCID 131585835-Fluoro-2-iodobenzoic acidHCID 670869485-fluoro-2-(2H-1,2,3-triazol-2-yl)benzoic acid

Product 1

HCID 670866272-Fluoro-6-(2H-1,2,3-triazol-2-yl)benzoic acid

Procedure

The title compound was prepared in a manner analogous to Intermediate 13, substituting 6-fluoro-2-iodo-benzoic acid for 5-fluoro-2-iodo-benzoic acid. 1H NMR (400 MHz, CD3OD): 7.96 (s, 2H), 7.87-7.82 (m, 1H), 7.70 (td, J=8.1, 5.1 Hz, 1H), 7.59 (ddd, J=9.7, 8.4, 1.4 Hz, 1H).

Sources & evidence

ORD record
ord-349f923fb0034532adcdf23e0a564f8e
Source dataset
uspto-grants-2014_03
Patent number
US08680275B2

Reaction notes

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