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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1193081Generated: November 2, 2026

2-Chloro-4-(trifluoromethyl)pyrimidine → (1R,6S)-8-(5-Methylpyrazin-2-yl)-3,8-diazabicyclo[4.2.0]octane

https://huagongshe.com/reaction/1193081

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Chloro-4-(trifluoromethyl)pyrimidineHCID 2773912—
ReactantHCID 67116508HCID 67116508—
Product(1R,6S)-8-(5-Methylpyrazin-2-yl)-3,8-diazabicyclo[4.2.0]octaneHCID 67116692—

Reaction Steps

The title compound was prepared in a manner analogous to Intermediate 27, substituting 2-bromo-5-methylpyrazine for 2-chloro-4-(trifluoromethyl)pyrimidine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08680275B2
Source datasetuspto-grants-2014_03
ORD IDord-ce72c4a54d3849939146f4165242903e
Source noteuspto-grants-2014_03