2-Chloro-4-(trifluoromethyl)pyrimidine → (1R,6S)-8-(6-Methylpyrazin-2-yl)-3,8-diazabicyclo[4.2.0]octane

HRID 1193082Notes

Reaction equation

HRID 1193082 reaction equation
F[C:2](F)(F)[C:3]1[CH:8]=CN=[C:5]([N:9]2[C@@H:16]3[C@@H:11]([CH2:12][CH2:13][NH:14][CH2:15]3)[CH2:10]2)[N:4]=1.Cl[C:20]1N=C(C(F)(F)F)C=C[N:21]=1>>[CH3:2][C:3]1[N:4]=[C:5]([N:9]2[C@@H:16]3[C@@H:11]([CH2:12][CH2:13][NH:14][CH2:15]3)[CH2:10]2)[CH:20]=[N:21][CH:8]=1

Participants

3

Reactant 2

HCID 27739122-Chloro-4-(trifluoromethyl)pyrimidineHCID 67116508HCID 67116508, compound

Product 1

HCID 67116766(1R,6S)-8-(6-Methylpyrazin-2-yl)-3,8-diazabicyclo[4.2.0]octane

Procedure

The title compound was prepared in a manner analogous to Intermediate 27, substituting 2-bromo-6-methylpyrazine for 2-chloro-4-(trifluoromethyl)pyrimidine.

Sources & evidence

ORD record
ord-79feb94a1b794e679851b03168bf67d9
Source dataset
uspto-grants-2014_03
Patent number
US08680275B2

Reaction notes

Loading…