HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetonitrile → 2-((1R,6S)-3,8-Diazabicyclo[4.2.0]octan-8-yl)-5-chlorobenzo[d]oxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2-Chloro-4-(trifluoromethyl)pyrimidine | HCID 2773912 | — |
| Reactant | HCID 67116508 | HCID 67116508 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-((1R,6S)-3,8-Diazabicyclo[4.2.0]octan-8-yl)-5-chlorobenzo[d]oxazole | HCID 67116781 | — |
Reaction Steps
The title compound was prepared in a manner analogous to Intermediate 27, substituting 2,5-dichlorobenzo[d]oxazole for 2-chloro-4-(trifluoromethyl)pyrimidine. In addition, DMF and K2CO3 at 95° C. was substituted for DIPEA and ACN.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08680275B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-858f1d809a974914ba1d01bf0d266172 |
| Source note | uspto-grants-2014_03 |