Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1193093Generated: November 1, 2026

6-Chloro-2-picoline → (1R,6S)-8-(4-Methylpyridin-2-yl)-3,8-diazabicyclo[4.2.0]octane

https://huagongshe.com/reaction/1193093

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-Chloro-2-picolineHCID 87601—
Reactant(1R,6S)-8-(6-Methylpyridin-2-yl)-3,8-diazabicyclo[4.2.0]octaneHCID 67116915—
Product(1R,6S)-8-(4-Methylpyridin-2-yl)-3,8-diazabicyclo[4.2.0]octaneHCID 67117266—

Reaction Steps

The title compound was prepared in a manner analogous to Intermediate 40, substituting 2-chloro-4-methylpyridine for 2-chloro-6-methylpyridine in step A. MS (ESI) mass calcd. for C12H17N3, 203.2; m/z found, 204.1 [M+H]+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08680275B2
Source datasetuspto-grants-2014_03
ORD IDord-2bb98ba2ccc34e57941994448ff466ec
Source noteuspto-grants-2014_03