1,2-Dimethoxyethane → (1R,6S)-tert-butyl 8-(4-(dimethylamino)pyridin-2-yl)-3,8-diazabicyclo[4.2.0]octane-3-carboxylate

Participants

Reaction Conditions

Reaction Steps

To a microwave safe vial was added Intermediate 40 (200 mg, 0.94 mmol), 2-chloro-N,N-dimethylpyridin-4-amine (134 mg, 0.85 mmol), chloro[(1,2,3-n)-3-phenyl-2-propenyl][1,3-bis(2,6-di-1-propylphenyl)-4,5-dihydroimidazol-2-ylidene]palladium(II) (5.6 mg, 0.0086 mmol), potassium tert-butoxide (96.1 mg, 0.85 mmol) and DME (8 mL). The resulting mixture was heated to 100° C. After 1 hour the mixture was allowed to cool to ambient temperature at which time water (20 mL) was added. The aqueous layer was extracted with DCM (15 mL) three times. The organic layers were combined, dried over Na2SO4, filtered, and concentrated under reduced pressure. The crude residue was purified by reverse-phase HPLC (basic) to yield (1R,6S)-tert-butyl 8-(4-(dimethylamino)pyridin-2-yl)-3,8-diazabicyclo[4.2.0]octane-3-carboxylate (150 mg, 52%). MS (ESI) mass calcd. for C18H28N4O2, 332.2; m/z found, 333.2 [M+H]+. 1H NMR (500 MHz, CDCl3): 7.84 (d, J=5.7 Hz, 1H), 6.02 (d, J=5.6 Hz, 1H), 5.45-5.31 (m, 1H), 4.47-4.35 (m, 1H), 4.09-3.96 (m, 1H), 3.91 (t, J=7.7 Hz, 1H), 3.86-3.72 (m, 2H), 3.55-3.26 (m, 2H), 2.95 (s, 6H), 2.85-2.70 (m, 1H), 2.06-1.95 (m, 1H), 1.90-1.84 (m, 1H), 1.45-1.29 (m, J=52.5 Hz, 9H).

Provenance & Evidence