2,4-Dichloro-5-fluoropyrimidine → 2-Chloro-4,5-dimethylpyrimidine

HRID 1193113Notes

Reaction equation

HRID 1193113 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([CH3:8])[C:5](F)=[CH:4][N:3]=1.Cl[C:11]1N=C(Cl)C(F)=CN=1>>[Cl:1][C:2]1[N:7]=[C:6]([CH3:8])[C:5]([CH3:11])=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 2507052,4-Dichloro-5-fluoropyrimidineHCID 207780732-Chloro-5-fluoro-4-methylpyrimidine

Product 1

HCID 125817842-Chloro-4,5-dimethylpyrimidine

Procedure

The title compound was prepared in a manner analogous to Intermediate 65, substituting 2,4-dichloro-5-methylpyrimidine for 2,4-dichloro-5-fluoropyrimidine. MS (ESI): mass calculated for C6H7ClN2, 142.03, m/z found 143.1 [M+1]+. 1H NMR (500 MHz, CDCl3): 8.32-8.25 (m, 1H), 2.52-2.46 (m, 3H), 2.28-2.22 (m, 3H).

Sources & evidence

ORD record
ord-38c1d055142147ca8d174cac49a21d4f
Source dataset
uspto-grants-2014_03
Patent number
US08680275B2

Reaction notes

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