2-Chloro-4,5,6-trimethylpyrimidine → 2-Chloro-5-ethyl-4,6-dimethylpyrimidine

HRID 1193119Notes

Reaction equation

HRID 1193119 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([CH3:8])[C:5]([CH3:9])=[C:4]([CH3:10])[N:3]=1.[CH3:11]C1C(C)=C(C)N=C(O)N=1>>[Cl:1][C:2]1[N:7]=[C:6]([CH3:8])[C:5]([CH2:9][CH3:11])=[C:4]([CH3:10])[N:3]=1

Participants

3

Reactant 2

HCID 125019872-Chloro-4,5,6-trimethylpyrimidineHCID 178433497HCID 178433497, compound

Product 1

HCID 198466592-Chloro-5-ethyl-4,6-dimethylpyrimidine

Procedure

The title compound was prepared in a manner analogous to Intermediate 66, substituting 5-ethyl-4,6-dimethylpyrimidin-2-ol for 4,5,6-trimethylpyrimidin-2-ol. MS (ESI): mass calculated for C8H11ClN2, 170.06, m/z found 171.1 [M+1]+. 1H NMR (500 MHz, CDCl3): 2.65 (q, J=7.6 Hz, 2H), 2.50 (s, 6H), 1.15 (t, J=7.6 Hz, 3H).

Sources & evidence

ORD record
ord-36d9f2b190db49f69e24d437c64275f8
Source dataset
uspto-grants-2014_03
Patent number
US08680275B2

Reaction notes

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