HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-fluoro-2-(1H-pyrazol-5-yl)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 3-fluoro-2-(1H-pyrazol-5-yl)benzonitrile | HCID 67116928 | — |
| Product | 3-fluoro-2-(1H-pyrazol-5-yl)benzoic acid | HCID 67086609 | 99% |
Reaction Steps
To 3-fluoro-2-(1H-pyrazol-5-yl)benzonitrile in MeOH (3 mL) was added 2M aq. NaOH (1 mL). The reaction was heated at reflux for 15 h, then cooled to rt, acidified with 1N aq. HCl to pH=1 and extracted with EtOAc to give (210 mg, 99%) of 3-fluoro-2-(1H-pyrazol-5-yl)benzoic acid which was used crude.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08680275B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-63935acda7ef4ca8aa135112a105a637 |
| Source note | uspto-grants-2014_03 |