HuagongsheHuagongshe Chemistry Print Report · For research reference only
o-Phenylbenzoic acid → Biphenyl-2-yl-[8-(4-phenyl-pyrimidin-2-yl)-3,8-diaza-bicyclo[4.2.0]oct-3-yl]-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | o-Phenylbenzoic acid | HCID 70357 | — |
| Reactant | 2-(Thiophen-2-yl)benzoic acid | HCID 5105623 | — |
| Reactant | 8-(4-Phenyl-pyrimidin-2-yl)-3,8-diaza-bicyclo[4.2.0]octane | HCID 67116749 | — |
| Reactant | (1R,6S)-8-(4,6-Dimethyl-pyrimidin-2-yl)-3,8-diaza-bicyclo[4.2.0]octane | HCID 68156939 | — |
| Product | Biphenyl-2-yl-[8-(4-phenyl-pyrimidin-2-yl)-3,8-diaza-bicyclo[4.2.0]oct-3-yl]-methanone | HCID 67117097 | — |
Reaction Steps
The title compound was prepared in a manner analogous to Example 1, substituting 8-(4-phenyl-pyrimidin-2-yl)-3,8-diaza-bicyclo[4.2.0]octane (Intermediate 6) for (1R,6S)8-(4,6-dimethyl-pyrimidin-2-yl)-3,8-diaza-bicyclo[4.2.0]octane and biphenyl-2-carboxylic acid for 2-thiophen-2-yl-benzoic acid. MS (ESI) mass calcd. for C29H26N4O, 446.54; m/z found, 447.3 [M+H]+. 1H NMR (400 MHz, CDCl3): 8.44-7.28 (m, 13H), 7.27-6.79 (m, 3H), 4.70-3.66 (m, 4H), 3.59-2.31 (m, 3H), 2.19-0.93 (M, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08680275B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-88d4df4bb25c490ea93894cf04120135 |
| Source note | uspto-grants-2014_03 |