HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,6-Dimethoxybenzoic Acid → (2,6-Dimethoxy-phenyl)-[8-(4-phenyl-pyrimidin-2-yl)-3,8-diaza-bicyclo[4.2.0]oct-3-yl]-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,6-Dimethoxybenzoic Acid | HCID 15109 | — |
| Reactant | 2-(Thiophen-2-yl)benzoic acid | HCID 5105623 | — |
| Reactant | 8-(4-Phenyl-pyrimidin-2-yl)-3,8-diaza-bicyclo[4.2.0]octane | HCID 67116749 | — |
| Reactant | (1R,6S)-8-(4,6-Dimethyl-pyrimidin-2-yl)-3,8-diaza-bicyclo[4.2.0]octane | HCID 68156939 | — |
| Product | (2,6-Dimethoxy-phenyl)-[8-(4-phenyl-pyrimidin-2-yl)-3,8-diaza-bicyclo[4.2.0]oct-3-yl]-methanone | HCID 67116788 | — |
Reaction Steps
The title compound was prepared in a manner analogous to Example 1, substituting 8-(4-phenyl-pyrimidin-2-yl)-3,8-diaza-bicyclo[4.2.0]octane (Intermediate 6) for (1R,6S)8-(4,6-dimethyl-pyrimidin-2-yl)-3,8-diaza-bicyclo[4.2.0]octane and 2,6-dimethoxy-benzoic acid for 2-thiophen-2-yl-benzoic acid. MS (ESI) mass calcd. for C25H26N4O3, 430.50; m/z found, 431.3 [M+H]+. 1H NMR (400 MHz, CDCl3): 7.60-7.27 (m, 7H), 7.25-6.66 (m, 3H), 4.84-2.46 (m, 12H), 2.18-1.15 (m, 4H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08680275B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-a9cb0ee8bc7a4ecc894c5d6ce58daa0f |
| Source note | uspto-grants-2014_03 |