2-(Thiophen-2-yl)benzoic acid → HCID 52918932, compound

Participants

Reaction Steps

The title compound was prepared in a manner analogous to Example 1, substituting (1R,6S)-[4-(3,8-diaza-bicyclo[4.2.0]oct-8-yl)-6-methyl-pyrimidin-2-yl]-dimethyl-amine (Intermediate 8) for (1R,6S)8-(4,6-dimethyl-pyrimidin-2-yl)-3,8-diaza-bicyclo[4.2.0]octane and 5-fluoro-2-[1,2,3]triazol-2-yl-benzoic acid (Intermediate 13) for 2-thiophen-2-yl-benzoic acid. MS (ESI) mass calcd. for C22H25FN8O, 436.49; m/z found 437.2 [M+H]+. 1H NMR (400 MHz, CDCl3): 8.14-6.61 (m, 5H), 5.82-5.45 (m, 1H), 4.75-3.27 (m, 6H), 3.22-2.55 (m, 8H), 2.37-1.78 m (m, 5H).

Provenance & Evidence