2-Chloro-4-phenylpyrimidine → HCID 52919177, compound

HRID 1193154Notes

Reaction equation

HRID 1193154 reaction equation
C12N(C3C=NC4C(=CC=CC=4)N=3)CC1CCNC2.[CH:19]12[CH2:25][NH:24][CH:23]1[CH2:22][N:21]([C:26]([C:28]1[N:29]=[C:30]([CH3:40])[S:31][C:32]=1[C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][C:34]=1[F:39])=[O:27])[CH2:20]2.Cl[C:42]1[N:47]=[C:46]([C:48]2[CH:53]=[CH:52][CH:51]=[CH:50][CH:49]=2)[CH:45]=[CH:44][N:43]=1>>[F:39][C:34]1[CH:35]=[CH:36][CH:37]=[CH:38][C:33]=1[C:32]1[S:31][C:30]([CH3:40])=[N:29][C:28]=1[C:26]([N:21]1[CH2:22][CH:23]2[CH:19]([CH2:25][N:24]2[C:42]2[N:47]=[C:46]([C:48]3[CH:53]=[CH:52][CH:51]=[CH:50][CH:49]=3)[CH:45]=[CH:44][N:43]=2)[CH2:20]1)=[O:27]

Participants

4

Reactant 3

HCID 6053562-Chloro-4-phenylpyrimidineHCID 671166512-(3,8-Diaza-bicyclo[4.2.0]oct-8-yl)-quinoxalineHCID 67116850HCID 67116850, compound

Product 1

HCID 52919177HCID 52919177, compound

Procedure

The title compound was prepared in a manner analogous to Intermediate 2, Step A, using Intermediate 21 and 2-chloro-4-phenyl-pyrimidine. MS (ESI) mass calcd. for C26H22FN5OS, 471.56; m/z found, 472.1 [M+H]+.

Sources & evidence

ORD record
ord-2ca503c065ad4ff58ce20253480fffcb
Source dataset
uspto-grants-2014_03
Patent number
US08680275B2

Reaction notes

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