2-Chloro-4,6-dimethylpyrimidine → HCID 52919181, compound

HRID 1193157Notes

Reaction equation

HRID 1193157 reaction equation
C12[N:8]([C:9]3C=N[C:16]4[C:11](=[CH:12]C=[CH:14][CH:15]=4)[N:10]=3)CC1CCNC2.[Br:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[C:26]([N:28]1[CH2:34][CH:33]2[CH:30]([CH2:31][NH:32]2)[CH2:29]1)=[O:27].ClC1N=C(C)C=C(C)N=1>>[Br:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[C:26]([N:28]1[CH2:34][CH:33]2[CH:30]([CH2:31][N:32]2[C:9]2[N:8]=[C:15]([CH3:14])[CH:16]=[C:11]([CH3:12])[N:10]=2)[CH2:29]1)=[O:27]

Participants

4

Reactant 3

HCID 205502-Chloro-4,6-dimethylpyrimidineHCID 671166512-(3,8-Diaza-bicyclo[4.2.0]oct-8-yl)-quinoxalineHCID 69932326HCID 69932326, compound

Product 1

HCID 52919181HCID 52919181, compound

Procedure

The title compound was prepared in a manner analogous to Intermediate 2, Step A, using Intermediate 23 and 2-chloro-4,6-dimethylpyrimidine. MS (ESI) mass calcd. for C18H19BrN4O, 387.28; m/z found, 389.1 [M+H]+.

Sources & evidence

ORD record
ord-228ba1e2ecd04880931d0b3feb0747f3
Source dataset
uspto-grants-2014_03
Patent number
US08680275B2

Reaction notes

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