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HRID1193173

反应详情

EQUATION

反应方程式

HRID 1193173 的结构方程式

REACTANTS

反应物

4
结构：O=C(O)c1ccccc1-c1cccs1
HCID5105623

2-(2-thienyl)benzoic acid

C11H8O2S

结构：O=C(O)c1cc(F)ccc1-n1nccn1
HCID67086948

未命名化合物

2 次

结构：Cc1cc(C)nc(N2C[C@@H]3CCNC[C@@H]32)n1
HCID68156939

未命名化合物

结构：Cc1cnc(C)c(N2C[C@@H]3CCNC[C@@H]32)n1
HCID68157557

未命名化合物

PRODUCTS

生成物

1
结构：Cc1cnc(C)c(N2C[C@@H]3CCN(C(=O)c4cc(F)ccc4-n4nccn4)C[C@@H]32)n1
HCID52920050

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

The title compound was prepared in a manner analogous to Example 1, substituting (1R,6S)-8-(3,6-Dimethyl-pyrazin-2-yl)-3,8-diaza-bicyclo[4.2.0]octane (Intermediate 10) for (1R,6S)8-(4,6-dimethyl-pyrimidin-2-yl)-3,8-diaza-bicyclo[4.2.0]octane and 5-fluoro-2-[1,2,3]triazol-2-yl-benzoic acid (Intermediate 13) for 2-thiophen-2-yl-benzoic acid. DCM was used in place of DMF. MS (ESI) mass calcd. For C21H22FN7O, 407.45; m/z found 408.2 [M+H]+. 1H NMR (CD3OD): 8.05-7.84 (m, 2H), 7.66-7.24 (m, 4H), 4.59-3.44 (m, 7H), 3.04-2.31 (m, 6H), 2.09-2.96 (m, 3H).