2-(Thiophen-2-yl)benzoic acid → HCID 52920053, compound

Participants

Reaction Steps

The title compound was prepared in a manner analogous to Example 1, substituting (1R,6S)-8-(5-methylpyrazin-2-yl)-3,8-diazabicyclo[4.2.0]octane (Intermediate 29) for (1R,6S)8-(4,6-dimethyl-pyrimidin-2-yl)-3,8-diaza-bicyclo[4.2.0]octane and 2-[1,2,3]triazol-2-yl-benzoic acid (Intermediate 14) for 2-thiophen-2-yl-benzoic acid. DCM was used in place of DMF. MS (ESI) mass calcd. For C20H21N7O, 375.44; m/z found 376.0 [M+H]+. 1H NMR (CDCl3): 8.06-7.78 (m, 3H), 7.72-7.44 (m, 3H), 7.39-7.28 (m, 1H), 7.16-6.96 (m, 1H), 4.56-3.98 (m, 4H), 3.80-2.96 (m, 4H), 2.46-2.03 (m, 5H).

Provenance & Evidence