2-(Thiophen-2-yl)benzoic acid → HCID 52920166, compound

Participants

Reaction Steps

The title compound was prepared in a manner analogous to Example 1, substituting (1R,6S)-8-(3-methylpyrazin-2-yl)-3,8-diazabicyclo[4.2.0]octane (Intermediate 31) for (1R,6S)8-(4,6-dimethyl-pyrimidin-2-yl)-3,8-diaza-bicyclo[4.2.0]octane and 5-fluoro-2-[1,2,3]triazol-2-yl-benzoic acid (Intermediate 13) for 2-thiophen-2-yl-benzoic acid. DCM was used in place of DMF. MS (ESI) mass calcd. For C20H20FN7O, 393.43; m/z found 394.1 [M+H]+. 1H NMR (CD3OD): 8.10-8.01 (m, 1H), 7.97-7.88 (m, 2H), 7.83-7.74 (m, 1H), 7.67-7.61 (m, 1H), 7.47-7.22 (m, 2H), 4.52-4.30 (m, 2H), 4.22-3.83 (m, 2H), 3.75-3.11 (m, 3H), 2.72-2.31 (m, 4H), 2.18-1.50 (m, 2H).

Provenance & Evidence