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HRID1193182

反应详情

EQUATION

反应方程式

HRID 1193182 的结构方程式

REACTANTS

反应物

4
结构：O=C(O)c1ccccc1-c1cccs1
HCID5105623

2-(2-thienyl)benzoic acid

C11H8O2S

结构：O=C(O)c1ccccc1-n1nccn1
HCID21313592

2-(2H-1,2,3-Triazol-2-yl)benzoic acid

C9H7N3O2

2 次

结构：Cc1cncc(N2C[C@@H]3CCNC[C@@H]32)n1
HCID67116766

(1R,6S)-8-(6-Methylpyrazin-2-yl)-3,8-diazabicyclo[4.2.0]octane

C11H16N4

结构：Cc1cc(C)nc(N2C[C@@H]3CCNC[C@@H]32)n1
HCID68156939

未命名化合物

PRODUCTS

生成物

1
结构：Cc1cncc(N2C[C@@H]3CCN(C(=O)c4ccccc4-n4nccn4)C[C@@H]32)n1
HCID67116683

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

The title compound was prepared in a manner analogous to Example 1, substituting (1R,6S)-8-(6-methylpyrazin-2-yl)-3,8-diazabicyclo[4.2.0]octane (Intermediate 30) for (1R,6S)8-(4,6-dimethyl-pyrimidin-2-yl)-3,8-diaza-bicyclo[4.2.0]octane and 2-[1,2,3]triazol-2-yl-benzoic acid (Intermediate 14) for 2-thiophen-2-yl-benzoic acid. DCM was used in place of DMF. MS (ESI) mass calcd. For C20H21N7O, 375.44; m/z found 376.1 [M+H]+. 1H NMR (CD3OD): 8.08-7.75 (m, 3H), 7.68-7.37 (m, 4H), 7.33-6.82 (m, 1H), 4.70-3.78 (m, 5H), 3.64-2.97 (m, 3H), 2.43-2.01 (m, 5H).