反应详情

The title compound was prepared in a manner analogous to Example 1, substituting 2-((1R,6S)-3,8-diazabicyclo[4.2.0]octan-8-yl)-5-chlorobenzo[d]oxazole (Intermediate 32) for (1R,6S)8-(4,6-dimethyl-pyrimidin-2-yl)-3,8-diaza-bicyclo[4.2.0]octane and 2-fluoro-6-[1,2,3]triazol-2-yl-benzoic acid (Intermediate 15) for 2-thiophen-2-yl-benzoic acid. DCM was used in place of DMF. MS (ESI) mass calcd. For C22H18ClFN6O2, 452.88; m/z found 453.0 [M+H]+. 1H NMR (CD3OD): 8.04-7.74 (m, 2H), 7.67-7.24 (m, 4H), 7.15-6.64 (m, 2H), 5.04-4.23 (m, 3H), 4.20-3.35 (m, 4H), 3.20 (br s, 1H), 2.37-1.88 (m, 2H).