2-(Thiophen-2-yl)benzoic acid → HCID 67116721, compound

HRID 1193191Notes

Reaction equation

HRID 1193191 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])N=[C:4]([N:9]2[C@@H:16]3[CH:11]([CH2:12][CH2:13][NH:14][CH2:15]3)[CH2:10]2)[N:3]=1.[F:17][C:18]1[CH:26]=[CH:25][CH:24]=[C:23]([N:27]2[N:31]=[CH:30][CH:29]=[N:28]2)[C:19]=1[C:20](O)=[O:21].S1C=CC=C1C1C=CC=CC=1C(O)=O>>[F:17][C:18]1[CH:26]=[CH:25][CH:24]=[C:23]([N:27]2[N:31]=[CH:30][CH:29]=[N:28]2)[C:19]=1[C:20]([N:14]1[CH2:13][CH2:12][C@@H:11]2[C@@H:16]([N:9]([C:4]3[CH:8]=[CH:6][CH:7]=[C:2]([CH3:1])[N:3]=3)[CH2:10]2)[CH2:15]1)=[O:21]

Participants

4

Reactant 3

HCID 51056232-(Thiophen-2-yl)benzoic acidHCID 670866272-Fluoro-6-(2H-1,2,3-triazol-2-yl)benzoic acidHCID 68156916HCID 68156916, compound

Product 1

HCID 67116721HCID 67116721, compound

Procedure

The title compound was prepared in a manner analogous to Example 1 substituting Intermediate 40 for (1R,RS)8-(4,6-dimethyl-pyrimidin-2-yl)-3,8-diaza-bicyclo[4.2.0]octane and 2-fluoro-6-(2H-1,2,3-triazol-2-yl)benzoic acid for 2-thiophene-2-yl-benzoic acid. MS (ESI) mass calcd. for O21H21FN6O, 392.4; m/z found, 393.2 [M+H]+.

Sources & evidence

ORD record
ord-48783634d22145a28de62de303192c73
Source dataset
uspto-grants-2014_03
Patent number
US08680275B2

Reaction notes

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