2-(Thiophen-2-yl)benzoic acid → HCID 67116880, compound

HRID 1193193Notes

Reaction equation

HRID 1193193 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])N=[C:4]([N:9]2[C@@H:16]3[C@@H:11]([CH2:12][CH2:13][NH:14][CH2:15]3)[CH2:10]2)[N:3]=1.[F:17][C:18]1[CH:19]=[CH:20][C:21]([N:27]2[N:31]=[CH:30][CH:29]=[N:28]2)=[C:22]([CH:26]=1)[C:23](O)=[O:24].S1C=CC=[C:33]1C1C=CC=CC=1C(O)=O>>[CH3:33][C:6]1[CH:7]=[C:2]([CH3:1])[N:3]=[C:4]([N:9]2[C@@H:16]3[C@@H:11]([CH2:12][CH2:13][N:14]([C:23]([C:22]4[CH:26]=[C:18]([F:17])[CH:19]=[CH:20][C:21]=4[N:27]4[N:31]=[CH:30][CH:29]=[N:28]4)=[O:24])[CH2:15]3)[CH2:10]2)[CH:8]=1

Participants

4

Reactant 3

HCID 51056232-(Thiophen-2-yl)benzoic acidHCID 670869485-fluoro-2-(2H-1,2,3-triazol-2-yl)benzoic acidHCID 68156939(1R,6S)-8-(4,6-Dimethyl-pyrimidin-2-yl)-3,8-diaza-bicyclo[4.2.0]octane

Product 1

HCID 67116880HCID 67116880, compound

Procedure

The title compound was prepared in a manner analogous to Example 1 substituting Intermediate 43 for (1R,6S)8-(4,6-dimethyl-pyrimidin-2-yl)-3,8-diaza-bicyclo[4.2.0]octane and 5-fluoro-2-(2H-1,2,3-triazol-2-yl)benzoic acid for 2-thiophene-2-yl-benzoic acid. MS (ESI) mass calcd. for C22H23FN6O, 406.5; m/z found, 408.2 [M+H]+.

Sources & evidence

ORD record
ord-148f985add8b4646a559172b01895a85
Source dataset
uspto-grants-2014_03
Patent number
US08680275B2

Reaction notes

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