Formic Acid → HCID 52920283, compound

Participants

Reaction Steps

(1R,6S)-8-(4,6-Dimethylpyrimidin-2-yl)-3-({5-fluoro-2-[1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-5-yl]phenyl}carbonyl)-3,8-diazabicyclo[4.2.0]octane (8 mg, 0.017 mmol) was combined with 6 M aq. HCl (8.154 mL, 0.05 mmol) in formic acid (2.5 mL, 0.75 mmol) and stirred for 90 min. The reaction mixture was concentrated from MeON (3×12 mL), then the mixture was dissolved in NH3 MeON and concentrated to neutralize acid. The residue was dissolved in CHCl3 and purified by FCC to afford the title compound (6.7 mg, 100%). MS (ESI) mass calcd. for C22H23FN6O, 406.5; m/z found, 407.2 [M+H]+.

Provenance & Evidence