HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,4-Diamino-6-chloropyrimidine → 6-[(1R,6S)-3-{[5-Fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]carbonyl}-3,8-diazabicyclo[4.2.0]oct-8-yl]pyrimidine-2,4-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,4-Diamino-6-chloropyrimidine | HCID 67432 | — |
| Reactant | (1R,6S)-3,8-diazabicyclo[4.2.0]octan-3-yl(5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone | HCID 67116560 | — |
| Reactant | 2-(3,8-Diaza-bicyclo[4.2.0]oct-8-yl)-quinoxaline | HCID 67116651 | — |
| Product | 6-[(1R,6S)-3-{[5-Fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl]carbonyl}-3,8-diazabicyclo[4.2.0]oct-8-yl]pyrimidine-2,4-diamine | HCID 69932674 | — |
Reaction Steps
The title compound was prepared in a manner analogous to Intermediate 2, Step A, using (1R,6S)-3,8-diazabicyclo[4.2.0]octan-3-yl(5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone and 4-chloro-2,6-diaminopyrimidine. MS (ESI) mass calcd. for C19H20FN9O, 409.4; m/z found, 410.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08680275B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-a3a625c9568b4c3ebfa4ffa9920da961 |
| Source note | uspto-grants-2014_03 |