HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-4,5,6-trimethylpyrimidine → (1R,6S)-8-(4,5,6-Trimethylpyrimidin-2-yl)-3,8-diazabicyclo[4.2.0]octane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-4,5,6-trimethylpyrimidine | HCID 12501987 | — |
| Reactant | cis-3-Boc-3,8-diazabicyclo[4.2.0]octane | HCID 16099092 | — |
| Reactant | (1R,6S)-8-(6-Methylpyridin-2-yl)-3,8-diazabicyclo[4.2.0]octane | HCID 67116915 | — |
| Product | (1R,6S)-8-(4,5,6-Trimethylpyrimidin-2-yl)-3,8-diazabicyclo[4.2.0]octane | HCID 67116795 | — |
Reaction Steps
(1R,6S)-8-(4,5,6-Trimethylpyrimidin-2-yl)-3,8-diazabicyclo[4.2.0]octane was prepared in a manner analogous to Intermediate 40, using Intermediate 66 and Intermediate 39 as starting materials. MS (ESI) mass calcd. for C13H20N4, 232.17; m/z found, 233.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08680275B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-556aedb435194865a0074f62e7bf3d93 |
| Source note | uspto-grants-2014_03 |