Trifluoroacetic acid → HCID 66805370, compound

Participants

Reaction Steps

TFA (25 ml) was added dropwise at 0° C. to a solution of (R)-methyl 3-(tert-butoxycarbonyl-(ethyl)amino)-2,3-dihydro-1H-indene-5-carboxylate (10.84 g, 33.97 mmol, 1 eq) in DCM (100 ml), and the mixture was stirred for 1 hour at RT. After monitoring by TLC, the reaction solution was concentrated under reduced pressure, the residue was taken up in sat. sodium hydrogen carbonate solution (500 ml) and extraction with ethyl acetate (3×1000 ml) was carried out. The combined org. phases were washed with sat. sodium chloride solution (800 ml), dried over sodium sulfate, concentrated and used in the following stage without being purified further. The desired product was in the form of a light-brown liquid. Yield: 91% (6.8 g, 31.05 mmol)

Provenance & Evidence