N,N-Dibenzyl-2-(1-(pyridin-4-yl)piperidin-4-yl)ethanamine → 2-[1-(Pyridin-4-yl)piperidin-4-yl]ethan-1-amine

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Reaction Steps

N,N-Dibenzyl-2-(1-(pyridin-4-yl)piperidin-4-yl)ethanamine (1.4 g, 3.63 mmol, 1 eq) was dissolved in ethanol (80 ml) and degassed for 30 min with nitrogen. 20% Pd(OH)2 (800 mg) was added and hydrogenation was carried out for 48 h at RT under balloon pressure (H2). After monitoring by thin-layer chromatography, the reaction mixture was filtered off over Celite and washed with ethanol (200 ml), and the filtrate was reduced under reduced pressure. Yield: 94% (700 mg, 3.41 mmol).

Provenance & Evidence