HCID 66799123, compound → HCID 66799294, compound

Participants

Reaction Steps

A solution of N-(4-methoxybenzyl)-N,3,3-trimethyl-1-(pyridin-4-yl)piperidin-4-amine (320 mg, 0.944 mmol, 1 eq) in MeOH (6 ml) was degassed for 15 min with nitrogen, then Pd(OH)2 (320 mg) was added and hydrogenation was carried out for 5 h at RT under balloon pressure (H2). After monitoring by thin-layer chromatography, the reaction mixture was filtered off over Celite and the filtrate was concentrated under reduced pressure. The crude product so obtained was used in the next stage without being purified further. Yield: 92% (190 mg, 0.867 mmol).

Provenance & Evidence