反应详情

4-(1,4-Dioxaspiro[4.5]dec-7-en-8-yl)pyridine (3.5 g, 16.1 mmol, 1 eq) was dissolved in MeOH (80 ml) and degassed for 15 min with argon. Pd(OH)2 (1.75 g, 50%) was added, and hydrogenation was carried out for 3 h at RT under balloon pressure (H2). After monitoring by thin-layer chromatography, the reaction mixture was filtered off over Celite and the filtrate was concentrated under reduced pressure. Yield: 84% (3.0 g, 13.6 mmol).

1. customdegassed for 15 min with argon
2. additionPd(OH)2 (1.75 g, 50%) was added
3. filtrationthe reaction mixture was filtered off over Celite
4. concentrationthe filtrate was concentrated under reduced pressure