反应详情

温度

40 °C

tert-Butyl methyl((1-(pyrimidin-4-yl)piperidin-4-yl)methyl)carbamate (0.718 mmol, 1 eq) was dissolved in ethanol (2.5 ml), and acetyl chloride (3.59 mmol, 5.0 eq) was added while cooling with ice. The reaction mixture was then stirred for 2 hours at 40° C. and then concentrated. The residue was taken up in a small amount of acetone and a solid was precipitated with diethyl ether. The solid was filtered off, washed with diethyl ether and dried. Yield: >99%

1. temperaturewhile cooling with ice
2. concentrationconcentrated
3. customa solid was precipitated with diethyl ether
4. filtrationThe solid was filtered off
5. washwashed with diethyl ether
6. customdried