Acetyl chloride → HCID 66798843, compound

Participants

Reaction Steps

tert-Butyl methyl(1-(3-(piperidin-1-yl)propanoyl)piperidin-4-yl)carbamate (2.461 mmol, 1 eq) was dissolved in ethanol (9 ml), and acetyl chloride (12.31 mmol, 5.0 eq) was added while cooling with ice. The reaction mixture was stirred for 16 hours at RT and then concentrated. The residue was taken up in a small amount of acetone, and a solid was precipitated by addition of diethyl ether. The solid was filtered off, washed with diethyl ether and dried. Yield: >99%

Provenance & Evidence