反应详情

温度

40 °C

tert-Butyl methyl(1-(pyrimidin-4-yl)piperidin-4-yl)carbamate (3.63 mmol, 1 eq) was dissolved in ethanol (13 ml), and acetyl chloride (18.13 mmol, 5.0 eq) was added while cooling with ice. The reaction mixture was then stirred for 2 hours at 40° C. The reaction mixture was concentrated under reduced pressure. A white precipitate formed from the concentrated solution. The suspension was diluted with diethyl ether and stirred for 1 hour at RT. Then the precipitate was filtered off with suction, washed with diethyl ether and dried. Yield: 96%

1. temperaturewhile cooling with ice
2. concentrationThe reaction mixture was concentrated under reduced pressure
3. customA white precipitate formed from the concentrated solution
4. stirringstirred for 1 hour at RT
5. filtrationThen the precipitate was filtered off with suction
6. washwashed with diethyl ether
7. customdried