HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1193351Generated: November 2, 2026
Acetyl chloride → N-Methyl-1-(2-methylpyridin-4-yl)azetidin-3-amine dihydrochloride
https://huagongshe.com/reaction/1193351
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | HCID 66805338 | HCID 66805338 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N-Methyl-1-(2-methylpyridin-4-yl)azetidin-3-amine dihydrochloride | HCID 66798562 | 99% |
Reaction Steps
tert-Butyl methyl(1-(2-methylpyridin-4-yl)azetidin-3-yl)carbamate (1.37 mmol, 1 eq) was dissolved in ethanol (5 ml), and acetyl chloride (6.85 mmol, 5.0 eq) was added while cooling with ice. The reaction mixture was then stirred for 2 hours at 40° C. The solvent was removed in vacuo and the residue was dried. Yield: 99%
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08680159B2 |
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| Source dataset | uspto-grants-2014_03 |
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| ORD ID | ord-38812cd7c0cf4d02b14a50fd280af129 |
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| Source note | uspto-grants-2014_03 |
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