Toluene → HCID 58235963, compound

Participants

Reaction Steps

(cis)-3-(4-Methylpiperazin-1-yl)cyclohexanamine trihydrochloride (5.0 g, 16.39 mmol, 1.0 eq.) and K2CO3 (9.05 g, 65.56 mmol, 4.0 eq.) were dissolved in water (15 ml); a solution of Cbz-C1 (2.85 g, 16.39 mmol, 1.0 eq.) in toluene (25 ml) was added at 0° C., and the reaction mixture was then stirred for 16 hours at RT. The reaction solution was diluted with water (15 ml) and the phases were separated. The org. phase was dried over sodium sulfate, concentrated under reduced pressure and purified by column chromatography (Alox, 1% MeOH in DCM). Yield: 37% (2.0 g, 6.04 mmol)

Provenance & Evidence